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dc.contributor.authorMendez, Gina
dc.contributor.authorTorrenegra G., Ruben Dario
dc.contributor.authorMuñoz Cendales, Diego Ricardo
dc.contributor.authorCelis, Crispin
dc.contributor.authorRoso, Michael
dc.contributor.authorGarzón , Jojhan
dc.contributor.authorBeltran, Ferney
dc.contributor.authorCardenas, Andres
dc.date.accessioned2023-02-14T20:28:11Z
dc.date.available2023-02-14T20:28:11Z
dc.date.issued2023
dc.identifier.citationMendez-Callejas, Gina, Ruben Torrenegra, Diego Muñoz, Crispin Celis, Michael Roso, Jojhan Garzon, Ferney Beltran, and Andres Cardenas. 2023. "A New Flavanone from Chromolaena tacotana (Klatt) R. M. King and H. Rob, Promotes Apoptosis in Human Breast Cancer Cells by Downregulating Antiapoptotic Proteins" Molecules 28, no. 1: 58. https://doi.org/10.3390/molecules28010058spa
dc.identifier.issn1420-3049spa
dc.identifier.urihttps://repository.udca.edu.co/handle/11158/5130
dc.description.abstractChromolaena tacotana is a source of flavonoids with antiproliferative properties in human breast cancer cells, the most common neoplasm diagnosed in patients worldwide. Until now, the mechanisms of cell death related to the antiproliferative activity of its flavonoids have not been elucidated. In this study, a novel flavanone (3′,4′-dihydroxy-5,7-dimethoxy-flavanone) was isolated from the plant leaves and identified by nuclear magnetic resonance (NMR) and mass spectrometry (MS). This molecule selectively inhibited cell proliferation of triple-negative human breast cancer cell lines MDA-MB-231 and MCF-7 whit IC50 values of 25.3 μg/mL and 20.8 μg/mL, respectively, determined by MTT assays with a selectivity index greater than 3. Early and late pro-apoptotic characteristics were observed by annexin-V/7-AAD detection, accompanied by a high percentage of the Bcl-2 anti-apoptotic protein inactivated and the activation of effector Caspase-3 and/or 7 in breast cancer cells. It was verified the decreasing of XIAP more than Bcl-2 anti-apoptotic proteins expression, as well as the XIAP/Caspase-7 and Bcl-2/Bax complexes dissociation after flavanone treatment. Docking and molecular modeling analysis between the flavanone and the antiapoptotic protein XIAP suggests that the natural compound inhibits XIAP by binding to the BIR3 domain of XIAP. In this case, we demonstrate that the new flavanone isolated from leaves of Chomolaena tacotana has a promising and selective anti-breast cancer potential that includes the induction of intrinsic apoptosis by downregulation of the anti-apoptotic proteins XIAP and Bcl-2. New studies should deepen these findings to demonstrate its potential as an anticancer agent.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.esspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://www.mdpi.com/1420-3049/28/1/58spa
dc.titleA New Flavanone from Chromolaena tacotana (Klatt) R. M. King and H. Rob, Promotes Apoptosis in Human Breast Cancer Cells by Downregulating Antiapoptotic Proteinseng
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.description.notesIncluye referencias bibliográficas.spa
dc.identifier.doihttps://doi.org/10.3390/molecules28010058
dc.subject.decsApoptosis
dc.subject.decsNeoplasias de la Mama
dc.subject.decsLínea Celular
dc.subject.decsApoptosis
dc.subject.decsProteína Inhibidora de la Apoptosis Ligada a X
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.subject.agrovocChromolaena
dc.relation.citationedition(Ene., 2023) 2023 Artículo 58spa
dc.relation.citationendpage16spa
dc.relation.citationissue1spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume28spa
dc.relation.ispartofjournalMoleculesspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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