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dc.contributor.authorHerrera-Acevedo, Chonny
dc.contributor.authorPerdomo Madrigal, Camilo
dc.contributor.authorMuratov, Eugene N.
dc.contributor.authorScotti, Marcus
dc.contributor.authorScotti, Marcus
dc.date.accessioned2021-08-11T16:39:21Z
dc.date.available2021-08-11T16:39:21Z
dc.date.issued2021
dc.identifier.citationHerrera-Acevedo, C., Perdomo-Madrigal, C., Muratov, E. N., Scotti, L., & Scotti, M. T. (2021). Discovery of alternative chemotherapy options for leishmaniasis through computational studies of asteraceae. ChemMedChem, 16(8), 1234-1245. doi:10.1002/cmdc.202000862spa
dc.identifier.urihttps://repository.udca.edu.co/handle/11158/4207
dc.description.abstractLeishmaniasis is a complex disease caused by over 20 Leishmania species that primarily affects populations with poor socioeconomic conditions. Currently available drugs for treating leishmaniasis include amphotericin B, paromomycin, and pentavalent antimonials, which have been associated with several limitations, such as low efficacy, the development of drug resistance, and high toxicity. Natural products are an interesting source of new drug candidates. The Asteraceae family includes more than 23 000 species worldwide. Secondary metabolites that can be found in species from this family have been widely explored as potential new treatments for leishmaniasis. Recently, computational tools have become more popular in medicinal chemistry to establish experimental designs, identify new drugs, and compare the molecular structures and activities of novel compounds. Herein, we review various studies that have used computational tools to examine various compounds identified in the Asteraceae family in the search for potential drug candidates against Leishmania.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.esspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202000862spa
dc.titleDiscovery of Alternative Chemotherapy Options for Leishmaniasis through Computational Studies of Asteraceaeeng
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.description.notesIncluye referencias bibliográficasspa
dc.identifier.doihttps://doi.org/10.1002/cmdc.202000862
dc.subject.decsLeishmaniasis
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.subject.agrovocAsteraceae
dc.relation.indexedAgrosaviaspa
dc.relation.citationedition(Abr. 20., 2021)spa
dc.relation.citationendpage1245spa
dc.relation.citationissue8spa
dc.relation.citationstartpage1234spa
dc.relation.citationvolume16spa
dc.relation.ispartofjournalChemMedChemspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_16ecspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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