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dc.contributor.authorRodríguez Bejarano, Oscar Hernán
dc.contributor.authorAvendaño, Catalina
dc.contributor.authorPatarroyo, Manuel-Alfonsospa
dc.date.accessioned2021-07-01T19:48:17Z
dc.date.available2021-07-01T19:48:17Z
dc.date.issued2021
dc.identifier.citationRodríguez-Bejarano, Oscar H., Catalina Avendaño, and Manuel A. Patarroyo 2021. "Mechanisms Associated with Trypanosoma cruzi Host Target Cell Adhesion, Recognition and Internalization" Life 11, no. 6: 534. https://doi.org/10.3390/life11060534spa
dc.identifier.urihttps://repository.udca.edu.co/handle/11158/4061
dc.description.abstractChagas disease is caused by the kinetoplastid parasite Trypanosoma cruzi, which is mainly transmitted by hematophagous insect bites. The parasite’s lifecycle has an obligate intracellular phase (amastigotes), while metacyclic and bloodstream-trypomastigotes are its infective forms. Mammalian host cell recognition of the parasite involves the interaction of numerous parasite and host cell plasma membrane molecules and domains (known as lipid rafts), thereby ensuring internalization by activating endocytosis mechanisms triggered by various signaling cascades in both host cells and the parasite. This increases cytoplasmatic Ca2+ and cAMP levels; cytoskeleton remodeling and endosome and lysosome intracellular system association are triggered, leading to parasitophorous vacuole formation. Its membrane becomes modified by containing the parasite’s infectious form within it. Once it has become internalized, the parasite seeks parasitophorous vacuole lysis for continuing its intracellular lifecycle, fragmenting such a vacuole’s membrane. This review covers the cellular and molecular mechanisms involved in T. cruzi adhesion to, recognition of and internalization in host target cells.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.esspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227291/spa
dc.titleMechanisms Associated with Trypanosoma cruzi Host Target Cell Adhesion, Recognition and Internalizationeng
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.identifier.doihttps://doi.org/10.3390/life11060534
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.subject.agrovocTrypanosoma cruzi
dc.subject.agrovocEnfermedad de chagas
dc.subject.agrovocAdhesión
dc.relation.indexedN/Aspa
dc.identifier.instnameUS National Library of Medicine National Institutes of Healthspa
dc.identifier.reponameUS National Library of Medicine National Institutes of Healthspa
dc.identifier.repourlhttps://www.ncbi.nlm.nih.gov/pmc/articlesspa
dc.relation.citationedition(Jun., 2021)spa
dc.relation.citationendpage23spa
dc.relation.citationissue6spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume11spa
dc.relation.ispartofjournalLifespa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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