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dc.contributor.authorDel Río Ospina, Luisaspa
dc.contributor.authorCamargo, Milenaspa
dc.contributor.authorSoto De León, Sara Ceciliaspa
dc.contributor.authorSánchez, Ricardospa
dc.contributor.authorMoreno Pérez, Darwin Andrésspa
dc.contributor.authorPatarroyo, Manuel Elkinspa
dc.contributor.authorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-08T17:23:55Zspa
dc.date.available2020-05-08T17:23:55Zspa
dc.date.issued2020spa
dc.identifier.citationDel Río-Ospina, L., Camargo, M., Soto-De León, S.C., Sánchez, R., Moreno-Pérez, D.A., Patarroyo, M.E., Patarroyo, M.A. Identifying the HLA DRB1-DQB1 molecules and predicting epitopes associated with high-risk HPV infection clearance and redetection (2020) Scientific Reports, 10 (1), art. no. 7306, .spa
dc.identifier.urihttps://udca.elogim.com:2054/articles/s41598-020-64268-xspa
dc.description.abstractSeveral determining factors are involved in HPV infection outcomes; human leukocyte antigen (HLA) polymorphisms have been described as related factors. This study has ascertained the effect of genetic variation on HLA-DRB1 and DQB1 genes on HPV-16/-18/-31/-33/-45 and -58 clearance and redetection in Colombian women. PCR and qPCR were used for viral identification and the Illumina MiSeq system was used for HLA-typing of cervical samples (n = 276). Survival models were adjusted for identifying alleles/haplotypes related to HPV clearance/redetection; L1/L2 protein-epitope binding to MHC-II molecules was also predicted. Significant associations suggested effects favouring or hampering clearance/redetection events depending on the viral type involved in infection, e.g. just DRB1*12:01:01G favoured HPV-16 (coeff: 4.8) and HPV-45 clearance (coeff: 12.65) whilst HPV-18 (coeff: 2E-15), HPV-31 (coeff: 8E-17) and HPV-58 hindered elimination (coeff: 1E-14). An effect was only observed for some alelles when configured as haplotypes, e.g. DRB1*04:07:01G (having the greatest frequency in the target population) was associated with DQB1*02:01:1G or *03:02:03. Epitope prediction identified 23 clearance-related peptides and 29 were redetection-related; eight might have been related to HPV-16/-18 and -58 persistence and one to HPV-18 elimination. HLA allele/haplotype relationship with the course of HPV infection (clearance/redetection) depended on the infecting HPV type, in line with the specific viral epitopes displayed.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.relation.ispartofseriesScientific Reports;Vol.10, No. 1, Dic 1 2020, Article number 7306 páginas 1-11spa
dc.rightsDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://udca.elogim.com:2054/articles/s41598-020-64268-xspa
dc.sourcehttps://www.scopus.com/search/form.uri?display=basicspa
dc.subject.meshEpítoposspa
dc.subject.meshGenesspa
dc.subject.meshHaplotiposspa
dc.subject.meshPapillomavirus Humanospa
dc.titleIdentifying the HLA DRB1-DQB1 molecules and predicting epitopes associated with high-risk HPV infection clearance and redetectionspa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doi10.1038/s41598-020-64268-xspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.armarcAntígenos HLAspa
dc.subject.proposalEpitopesspa
dc.subject.proposalHaplotype HLAspa
dc.subject.proposalVPHspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
Except where otherwise noted, this item's license is described as Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales