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dc.contributor.authorLeJeume, Timothy M.spa
dc.contributor.authorTsui, Hei Yinspa
dc.contributor.authorParsons, Laura B.spa
dc.contributor.authorMiller, Gerald E.spa
dc.contributor.authorWhitted, Crystalspa
dc.contributor.authorLynch, Kayla E.spa
dc.contributor.authorRamsauer, Robert E.spa
dc.date.accessioned2019-11-28T21:01:49Zspa
dc.date.available2019-11-28T21:01:49Zspa
dc.date.issued2015spa
dc.identifier.citationLeJeune TM, Tsui HY, Parsons LB, Miller GE, Whitted C, et al. (2015) Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. PLOS ONE 10(11): e0142928. https://doi.org/10.1371/journal.pone.0142928spa
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142928spa
dc.description.abstractApoptosis can be triggered in two different ways, through the intrinsic or the extrinsic pathway. The intrinsic pathway is mediated by the mitochondria via the release of cytochrome C while the extrinsic pathway is prompted by death receptor signals and bypasses the mitochondria. These two pathways are closely related to cell proliferation and survival signaling cascades, which thereby constitute possible targets for cancer therapy. In previous studies we introduced two plant derived isomeric flavonoids, flavone A and flavone B which induce apoptosis in highly tumorigenic cancer cells of the breast, colon, pancreas, and the prostate. Flavone A displayed potent cytotoxic activity against more differentiated carcinomas of the colon (CaCo-2) and the pancreas (Panc28), whereas flavone B cytotoxic action is observed on poorly differentiated carcinomas of the colon (HCT 116) and pancreas (MIA PaCa). Apoptosis is induced by flavone A in better differentiated colon cancer CaCo-2 and pancreatic cancer Panc 28 cells via the intrinsic pathway by the inhibition of the activated forms of extracellular signal-regulated kinase (ERK) and pS6, and subsequent loss of phosphorylation of Bcl-2 associated death promoter (BAD) protein, while apoptosis is triggered by flavone B in poorly differentiated colon cancer HCT 116 and MIA PaCa pancreatic cancer cells through the extrinsic pathway with the concomitant upregulation of the phosphorylated forms of ERK and c-JUN at serine 73. These changes in protein levels ultimately lead to activation of apoptosis, without the involvement of AKT.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.relation.ispartofseriesPLoS ONE ;Vol. 10, No. 11, Nov. , 2015, Artículo No.e0142928spa
dc.rightsDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://udca.elogim.com:2092/record/display.uri?eid=2-s2.0-84960156975&origin=resultslist&zone=contextBoxspa
dc.subject.meshApoptosisspa
dc.subject.meshProteína Letal Asociada a bclspa
dc.subject.meshCaspasa 10spa
dc.subject.meshCaspasa 8spa
dc.subject.meshCaspasa 9spa
dc.subject.meshCiclo celularspa
dc.subject.meshDiferenciación celularspa
dc.subject.meshLínea Celular Tumoralspa
dc.subject.meshProliferación Celularspa
dc.titleMechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Statusspa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.description.notesIncluye bibliografiaspa
dc.identifier.doi10.1371/journal.pone.0142928spa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.proposalApoptosisspa
dc.subject.proposalbcl-Associated Death Proteinspa
dc.subject.proposalCaspase 10spa
dc.subject.proposalCaspase 8spa
dc.subject.proposalCaspase 9spa
dc.subject.proposalCell Cyclespa
dc.subject.proposalCell Differentiationspa
dc.subject.proposalCell Line, Tumorspa
dc.subject.proposalCell Proliferationspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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