https://repository.udca.edu.co/handle/11158/2220
Title: | Synthesis and in vitro antiproliferative activity of flavone and 6-hydroxyflavone oxime ethers derivatives |
Authors: | Díaz, John E. Martinez, Diana C. López, Lina V. Mendez, Gina M. Vera, Ricardo Loaiza, Alix E. |
Issue Date: | 2018 |
Citation: | Díaz, J. E., Martinez, D. C., López, L. V., Mendez, G. M., Vera, R., & Loaiza, A. E. (2018). Synthesis and in vitro antiproliferative activity of flavone and 6-hydroxyflavone oxime ethers derivatives. Journal of the Brazilian Chemical Society, 29(1), 177-184. doi:10.21577/0103-5053.20170128 |
Series/Report no.: | Journal of the Brazilian Chemical Society;Vol.29, No.1, Ene 2018 páginas 177-184 |
Abstract: | Herein we report the synthesis of a series of O-alkyl oximes of flavone and 6-hydroxyflavone using a simple experimental protocol under solvent free conditions with yields up to 87%. Cytotoxicity of all compounds was evaluated against MDA-MB-231, PC-3, A-549 and MRC-5 cells. IC50 values for two compounds were determined to be in the range 28.7-47.8 μM against all tested cell lines. Oxime ethers derivatives showed IC50 values between 28.7 and 49.5 μM against MDA-MB-231, while the best activity was obtained for 6-hydroxyflavone with an IC50 of 3.4 μM against this cell line. Compounds containing the substituent hydroxyl at the position six of flavone system displayed the best antiproliferative activity over MDA-MB-231 cells, being necessary this group to improve the sensibility on this type of cells. The antiproliferative activity of 6-hydroxyflavone is drastically diminished when the carbonyl group of flavone is changed by an oxime ether. |
URI: | http://jbcs.sbq.org.br/imagebank/pdf/2017-0062AR.pdf |
Appears in Collections: | CCB. Artículos indexados en Scopus |
File | Description | Size | Format | |
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Synthesis and in vitro Antiproliferative.pdf | 494,32 kB | Adobe PDF | ![]() View/Open |
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