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Title: Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans
Authors: Suárez, Carlos F.
Pabón, Laura
Barrera, Ana
Aza Conde, Jorge
Patarroyo, Manuel Alfonso
Patarroyo, Manuel Elkin
Issue Date: 2017
Citation: Suárez, C. F., Pabón, L., Barrera, A., Aza-Conde, J., Patarroyo, M. A., & Patarroyo, M. E. (2017). Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans. Biochemical and Biophysical Research Communications, 491(4), 1062-1069. doi:10.1016/j.bbrc.2017.08.012
Series/Report no.: Biochemical and Biophysical Research Communications;Vo., 491, No. 4 Sep., 30, 2017 páginas 1062-1069
Abstract: More than 50 years ago the owl monkey (genusAotus) was found to be highly susceptible to developinghuman malaria, making it an excellent experimental model for this disease. Microbes and parasites'(especially malaria) tremendous genetic variability became resolved during our malaria vaccine devel-opment, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPsare immunologically silent and must be specially modified (mHABPs) to induce a perfectfit into majorhistocompatibility complex (MHC) molecules (HLA in humans). Since malarial immunity is mainlyantibody-mediated and controlled by the HLA-DRB genetic region, ~1000Aotushave been molecularlycharacterised for MHC-DRB, revealing striking similarity between human andAotusMHC-DRB reper-tories. Such convergence suggested that a large group of immune protection-inducing protein structures(IMPIPS), highly immunogenic and protection inducers against malarial intravenous challenge inAotus,could easily be used in humans for inducing full protection against malaria. We highlight the value of alogical and rational methodology for developing a vaccine in an appropriate animal model:Aotusmonkeys
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