|Title:||Specific β-turns precede PPIIL structures binding to allele-specific HLA-DRβ1* PBRs in fully-protective malaria vaccine components|
Alba, Martha p.
Patarroyo, Manuel A.
Patarroyo, Manuel Elkin
|Citation:||Bermudez, A., Alba, M. P., Vanegas, M., Patarroyo, M. A., & Patarroyo, M. E. (2018). Specific β-turns precede PPIIL structures binding to allele-specific HLA-DRβ1* PBRs in fully-protective malaria vaccine components. Frontiers in Chemistry, 6(APR) doi:10.3389/fchem.2018.00106|
|Series/Report no.:||Frontiers in Chemistry;Vol.6 Abr 1. 2018 páginas 1-10|
|Abstract:||The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.|
|Appears in Collections:||CCB. Artículos indexados en Scopus|
|Specific b-Turns Precede.pdf||7,08 MB||Adobe PDF|
This item is licensed under a Creative Commons License