https://repository.udca.edu.co/handle/11158/2164
Title: | Specific β-turns precede PPIIL structures binding to allele-specific HLA-DRβ1* PBRs in fully-protective malaria vaccine components |
Authors: | Bermudez, Adriana Alba, Martha p. Vanegas, Magnolia Patarroyo, Manuel A. Patarroyo, Manuel Elkin |
Issue Date: | 2018 |
Citation: | Bermudez, A., Alba, M. P., Vanegas, M., Patarroyo, M. A., & Patarroyo, M. E. (2018). Specific β-turns precede PPIIL structures binding to allele-specific HLA-DRβ1* PBRs in fully-protective malaria vaccine components. Frontiers in Chemistry, 6(APR) doi:10.3389/fchem.2018.00106 |
Series/Report no.: | Frontiers in Chemistry;Vol.6 Abr 1. 2018 páginas 1-10 |
Abstract: | The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. |
URI: | https://www.frontiersin.org/articles/10.3389/fchem.2018.00106/full |
Appears in Collections: | CCB. Artículos indexados en Scopus |
File | Description | Size | Format | |
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Specific b-Turns Precede.pdf | 7,08 MB | Adobe PDF | ![]() View/Open |
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