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dc.contributor.authorZheng, Zhichaospa
dc.contributor.authorDíaz Arévalo, Dianaspa
dc.contributor.authorGuan, Hongbingspa
dc.contributor.authorZeng, Mingtaospa
dc.date.accessioned2019-09-19T20:35:49Zspa
dc.date.available2019-09-19T20:35:49Zspa
dc.date.issued2018spa
dc.identifier.urihttps://udca.elogim.com:2072/doi/pdf/10.1080/21645515.2018.1461296?needAccess=truespa
dc.description.abstractThe development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.relation.ispartofseriesHuman Vaccines and Immunotherapeutics;Vol.14, No.7, Jul 3. 2018 páginas 1717-1733spa
dc.rightsDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://udca.elogim.com:2072/doi/pdf/10.1080/21645515.2018.1461296?needAccess=truespa
dc.sourcehttps://www2.scopus.com/search/form.uri?display=bspa
dc.subject.meshBacteriasspa
dc.subject.meshEnsayo Clínicospa
dc.subject.meshPreparaciones Farmacéuticasspa
dc.subject.meshInfecciones Bacterianasspa
dc.subject.meshEnfermedades transmisiblesspa
dc.titleNoninvasive vaccination against infectious diseasesspa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.identifier.doi10.1080/21645515.2018.1461296spa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.proposalBacteriaspa
dc.subject.proposalClinical trialspa
dc.subject.proposalInfectious diseasespa
dc.subject.proposalIntranasalspa
dc.subject.proposalMicroneedlespa
dc.subject.proposalNoninvasivespa
dc.subject.proposalOralspa
dc.subject.proposalTranscutaneousspa
dc.subject.proposalVaccinespa
dc.subject.proposalVirusspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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