Anti-inflammatory effect of the hydroalcoholic extract of Muehlenbeckia tamnifolia (Kunth) meins leaves in a rat paw model

Abstract

Inflammation is the local or systemic process by which a vascularized tissue defends itself against different situations through cellular and molecular mediators (references of molecules and inflammatory cells) that play a primordial role in the maintenance of the organism homeostasis. Classically its treatment has required the intervention of different agents like Anti-inflammatory Non-Steroidal (NSAIDs), Corticosteroids and biological therapy; these drugs, despite being effective, have many side effects. The purpose of this research is to evaluate the anti-inflammatory activity of the hydroalcoholic extract of leaves of the plant species Muehlembeckia tamnifolia (Kunth) Meins in a rat model. 20 female Wistar rats were randomly distributed in 4 groups of 5 animals each; inflammation was induced by the injection of 0.1 ml of a 1% lambda-carrageenan solution into the plantar aponeurosis of the right paw of the rats. Group I and II were treated with the complete Muehlembeckia, at different doses, Group III was positive control (Diclofenac) and Group IV was negative control (water). With the lowest dose of the extract had a lower net volum