Show simple item record

dc.contributor.authorTorrenegra Guerrero, Rubén Daríospa
dc.contributor.authorRodriguez Mayusa, J.spa
dc.contributor.authorMendez Callejas, G.M.spa
dc.contributor.authorCanter, R.spa
dc.contributor.authorWhitted, C.spa
dc.contributor.authorPalau, V.E.spa
dc.date.accessioned2019-09-11T23:21:02Zspa
dc.date.available2019-09-11T23:21:02Zspa
dc.date.issued2018spa
dc.identifier.citationTorrenegra-Guerrero, R.D., Rodriguez-Mayusa, J., Mendez-Callejas, G.M., Canter, R., Whitted, C., Palau, V.E. Antiproliferative activity of extracts of Gnaphalium Gracile H.B.K. against cancer cell lines (2018) Pharmacologyonline, 2, pp. 113-122.spa
dc.identifier.urihttps://pharmacologyonline.silae.it/searchspa
dc.description.abstractEthanol and n-hexane extracts obtained from the leaves and inflorescences of Gnaphalium gracile, were tested at different concentrations to evaluate their antineoplastic activities on pancreatic, colon, and prostate cancer cell lines by examining mitochondrial function. The polar extracts of both, leaves and inflorescences which contain gnaphalin, quercetin, and 3-methoxy quercetin, exhibited cytotoxicity against every cell line tested with EC50 values ranging between 20.23±1.185 µg/mL and 70.71±1.1419 µg/mL. The most remarkable values were observed in pancreatic cancer Panc 28 and androgen-dependent prostate LnCaP cells, with EC50 values of 20.23±1.185 and ˂25µg/mL, and androgen-independent prostate cancer PC-3, colon HCT-116 and pancreatic MIA PaCa cells with values ranging between 28.84±1.1766 and 34.41±1.057 µg/mL. The non-polar extract derived from leaves demonstrated significant cytotoxicity towards colon cancer HCT-116 cells, with an EC50 of 39.46±1.0617 µg/mL. However, the non-polar extract from the inflorescences did not have an appreciable effect on cell proliferation of any of the cell lines tested except for androgen-independent prostate cancer PC-3 cells with an EC50 of 62.05±1.237 µg/mL. The data obtained support the traditional use of G. gracile and suggest the polar extracts from aerial parts, as an interesting source for the development of novel antineoplastic agents.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.relation.ispartofseriesPharmacologyonline;Vol.2 Ago 30 2018 páginas 113-122spa
dc.rightsDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://www.scopus.com/search/form.uri?display=basicspa
dc.sourcehttps://pharmacologyonline.silae.it/searchspa
dc.subject.meshNeoplasias Pancreáticasspa
dc.subject.meshNeoplasias de la Próstataspa
dc.subject.meshGnaphaliumspa
dc.subject.meshHelichrysumspa
dc.subject.meshAceites Volátilesspa
dc.titleAntiproliferative activity of extracts of Gnaphalium Gracile H.B.K. against cancer cell linesspa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.proposalAnti-neoplastic activityspa
dc.subject.proposalColon cancerspa
dc.subject.proposalGnaphalium gracilespa
dc.subject.proposalPancreatic cancerspa
dc.subject.proposalProstate cancerspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
Except where otherwise noted, this item's license is described as Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales