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dc.contributor.authorCentanaro, C. Naslyspa
dc.contributor.authorTorrenegra Guerrero, Rubén Daríospa
dc.contributor.authorPombo O., Luis M.spa
dc.contributor.authorCadavid, G., Vannesa.spa
dc.contributor.authorRodríguez, A., Oscar. E.spa
dc.date.accessioned2019-09-04T20:39:21Zspa
dc.date.available2019-09-04T20:39:21Zspa
dc.date.issued2018spa
dc.identifier.citationCentanaro, C.N., Torrenegra, G.R.D., Pombo, O.L.M., Cadavid, G.V., Rodríguez, A.O.E. Acute toxicity evaluation of the ethanolic extract from leaves and flowers of chromolaena perglabra (b. l. robinson) king & h. rob. (2018) Pharmacologyonline, 3, pp. 136-144.spa
dc.identifier.urihttps://pharmacologyonline.silae.it/files/archives/2018/vol3/PhOL_2018_3_A015_Centanaro.pdfspa
dc.description.abstractAt present, there is a great variety of plant species widely distributed in different geographical regions worldwide, with phytopharmacological potential; however, its indiscriminate use has limited access to vegetal resources by the population in general and the scientific community. Additionally, the lack of toxicological studies that provide knowledge on the safety of their use makes the problem more critical. According to traditional knowledge, the species that belong to the genus Chromolaena, have a high pharmacological potential, but currently, there are no studies that validate traditional use and safety. Therefore, the purpose of this investigation was to evaluate the acute toxicity of the leaf and flower extract of Chromolaena perglabra (C. perglabra) in mice. To develop this aim, 25 female ICR-CD1 mice were divided into two groups with three and two subgroups respectively, to which they were administered intraperitoneally 125, 250, 500, 1000 and 2000 mg/ kg of the ethanolic extract of leaves and flowers of C. perglabra; another 5 mice were administered the vehicle (control group); 72 hours after inoculation, they were sacrificed for histopathological study (macroscopic and microscopic). An increase in size was observed with mild lymphoid hyperplasia in the spleen and toxic hepatitis in all the animals, the rest of the organs analyzed were in normal conditions.eng
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.relation.ispartofseriesPharmacologyonline;Vol.3, Dic 30. 2018 páginas 136-144spa
dc.rightsDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://www.scopus.com/search/form.uri?display=basicspa
dc.sourcehttps://pharmacologyonline.silae.it/files/archives/2018/vol3/PhOL_2018_3_A015_Centanaro.pdfspa
dc.subject.meshToxicidad Agudaspa
dc.subject.meshAsteraceaespa
dc.subject.meshPlantas Medicinalesspa
dc.titleAcute toxicity evaluation of the ethanolic extract from leaves and flowers of chromolaena perglabra (b. l. robinson) king & h. rob.spa
dc.typeArtículo de revistaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.proposalAcute toxicitspa
dc.subject.proposalAsteraceaespa
dc.subject.proposalChromolaena perglabraspa
dc.subject.proposalMedicinal plantsspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.subject.agrovocChromolaenaspa
dc.subject.agrovocAsteraceaespa
dc.subject.agrovocVernoniaspa
dc.subject.agrovocAsteraceaespa
dc.relation.indexedAgriculturaspa
dc.type.contentTextspa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa


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Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
Except where otherwise noted, this item's license is described as Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales