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The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use
(2021)
Thirty-five peptides selected from functionally-relevant SARS-CoV-2 spike (S), membrane (M), and envelope (E) proteins were suitably modified for immunising MHC class II (MHCII) DNA-genotyped Aotus monkeys and matched with ...
Stereo electronic principles for selecting fully-protective, chemically-synthesised malaria vaccines
(2022)
Major histocompatibility class II molecule-peptide-T-cell receptor (MHCII-p-TCR) complex-mediated antigen presentation for a minimal subunit-based, multi-epitope, multistage, chemically-synthesised antimalarial vaccine is ...
Identification of Babesia bovis MSA-1 functionally constraint regions capable of binding to bovine erythrocytes
(2022)
Merozoite surface antigen-1 is a glycoprotein expressed by Babesia bovis and is considered a vaccine candidate given that antibodies against it are able to partially block in vitro invasion of bovine erythrocytes. Despite ...
Diagnostic Potential of the Serological Response to Synthetic Peptides from Mycobacterium tuberculosis Antigens for Discrimination Between Active and Latent Tuberculosis Infections
(2022)
Diagnosis and treatment of active tuberculosis (ATB) as well as latent tuberculosis infection (LTBI) are required for efective tuberculosis (TB) control, especially in TB endemic area. The usefulness of conventional tests ...
Semi-empirical quantum evaluation of peptide – MHC class II binding
(2017)
Peptide presentation by the major histocompatibility complex (MHC) is a key process for triggering a specific immune response. Studying peptide-MHC (pMHC) binding from a structural-based approach has potential for reducing ...
Invasion-inhibitory peptides chosen by natural selection analysis as an antimalarial strategy
(2023)
Plasmodium vivax's biological complexity has restricted in vitro culture development for characterising antigens involved in erythrocyte invasion and their immunological relevance. The murine model is proposed as a suitable ...
Babesia bovis RON2 binds to bovine erythrocytes through a highly conserved epitope
(2024)
B. bovis invasion of bovine erythrocytes requires tight junction formation involving AMA-1/RON2 complex
interaction. RON2 has been considered a vaccine candidate since antibodies targeting the protein can inhibit
parasite ...