Buscar
Mostrando ítems 1-10 de 17
Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model
(2019)
Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that 219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. ...
Plasmodium vivax in vitro continuous culture: The spoke in the wheel
(2018)
Understanding the life cycle of Plasmodium vivax is fundamental for developing strategies aimed at controlling and eliminating this parasitic species. Although advances in omic sciences and high-throughput techniques in ...
Plasmodium vivax Pv12 B-cell epitopes and HLA-DRβ1-dependent T-cell epitopes in vitro antigenicity
(2018)
Malaria is an infectious disease caused by parasites from the genus Plasmodium (P. falciparum and P. vivax are responsible for 90% of all clinical cases); it is widely distributed throughout the world’s tropical and ...
Sexual forms obtained in a continuous in vitro cultured Colombian strain of Plasmodium falciparum (FCB2)
(2020)
Background: The epidemiological control of malaria has been hampered by the appearance of parasite resistance to anti-malarial drugs and by the resistance of mosquito vectors to control measures. This has also been associated ...
What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?
(2017)
Malaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an ...
On the evolution and function of Plasmodium vivax reticulocyte binding surface antigen (pvrbsa)
(2018)
The RBSA protein is encoded by a gene described in Plasmodium species having tropism for reticulocytes. Since this protein is antigenic in natural infections and can bind to target cells, it has been proposed as a potential ...
Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective
(2017)
Abstract: Synthetic peptides have become invaluable biomedical research and medicinal chemistry tools for studying functional roles, i.e., binding or proteolytic activity, naturally-occurring regions’ immunogenicity in ...
Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases
(2020)
Malaria remains a large-scale public health problem, killing more than 400,000 people and infecting up to 230 million worldwide, every year. Unfortunately, despite numerous efforts and research concerning vaccine development, ...
The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development
(2017)
Analysis of ourPlasmodium falciparummalaria parasite peptides'1H-NMR database in the search for H-bonds andp-interactions led us to correlate their presence or absence with a peptide's particularimmunological behavior. It ...
Easy and fast method for expression and native extraction of Plasmodium vivax Duffy binding protein fragments
(2018)
Background: The Plasmodium vivax Duffy binding protein (PvDBP) has been the most studied ligand binding human reticulocytes to date. This molecule has a cysteine-rich domain in region II (RII) which has been used as control ...