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Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model
(2019)
Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that 219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. ...
p-Methoxyphenol: A potent and effective scavenger for solid-phase peptide synthesis
(2020)
During the final step of t-Boc/Bzl, solid-phase peptide synthesis (SPPS)-protecting groups from amino acids (aa) side chains must be removed from the target peptides during cleavage from the solid support. These reaction ...
Erratum: Publisher Correction: Mass & secondary structure propensity of amino acids explain their mutability and evolutionary replacements
(2018)
Why is an amino acid replacement in a protein accepted during evolution? The answer given by bioinformatics relies on the frequency of change of each amino acid by another one and the propensity of each to remain unchanged. ...
A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations
(2021)
Analysing pig class II mayor histocompatibility complex (MHC) molecules is mainly related to antigen presentation. Identifying frequently-occurring alleles in pig populations is an important aspect to be considered when ...
Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development
(2017)
A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), ...
Shorter antibacterial peptide having high selectivity for e. Coli membranes and low potential for inducing resistance
(2020)
Antimicrobial peptides (AMPs) have been recognised as a significant therapeutic option for mitigating resistant microbial infections. It has been found recently that Plasmodium falciparum-derived, 20 residue long, peptide ...
Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors
(2017)
Investigating whether high-risk human papillomavirus (HR-HPV) types tend to become grouped in a particular way and whether factors are associated with such grouping is important for measuring the real impact of vaccination. ...
Association of HIV status with infection by multiple HPV types
(2018)
Objectives: To identify the clinical and demographic characteristics of HIV-positive and HIV-negative women infected by multiple HPV types. Methods: 1399 women participated in the study (240 HIV-positive and 1159 HIV-negative ...
Functionally relevant proteins in Plasmodium falciparum host cell invasion
(Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2017, 2017)
A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins ...
Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases
(2020)
Malaria remains a large-scale public health problem, killing more than 400,000 people and infecting up to 230 million worldwide, every year. Unfortunately, despite numerous efforts and research concerning vaccine development, ...