Application of Vincristine via subcutaneous and autohemotransfusion as an adjuvant in the treatment of papal canal in adult canine. Report of a case
Multiple oral papillomatosis in young dogs (PVOC) is a benign neoplastic proliferative epithelium, caused by a virus of the Papovaviridae family, frequently found in canines, at the level of mucocutaneous zones: eyelids and, more commonly, at the lips, oral mucosa, tongue and cheeks. Contagious, with incubation period of approximately one month, rapid resolution without treatment or great proliferation that can cause dysphagia and pity. It is usually treated with various drugs until surgical resection. The objective of the study was to demonstrate that vincristine can be applied subcutaneously without producing the slightest irritation, and the number of applications is ostensibly reduced, prior to the application of autohemotransfusion as adjuvant treatment. It was carried out in a male canine, Siberian husky of two years of age, with 22 kg of weight, who was taken to consultation, presenting multiple nodulations of whitish aspect on the inner side of the lips. He was diagnosed with oral papillomatosis and an initial autohemotherapy therapy was established, extracting 10 ml of blood through the cephalic vein and injecting it immediately intramuscularly in the posterior limb contrary to the anterior limb from where it was taken; on the following three days, 0.5 ml of Vincristine was applied subcutaneously (Dosage of 0.025 mg / kg), (1 mg diluted in 10 ml of Benzyl Alcohol and 0.9% Sodium Chloride), repeated a week later , appreciating the total disappearance of the nodulations and without the presence of inflammatory reaction in the area of application.