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Association of HIV status with infection by multiple HPV types

Camargo, Milena; Del Río Ospina, Luisa; Soto-De León, Sara Cecilia; Sánchez, Ricardo Andrea; Pineda Peña, Clemencia; Sussmann, Otto; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alfonso (2018)

Objectives: To identify the clinical and demographic characteristics of HIV-positive and HIV-negative women infected by multiple HPV types. Methods: 1399 women participated in the study (240 HIV-positive and 1159 HIV-negative ...
Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors

Del Río-Ospina, Luisa; Soto de León, Sara Cecilia; Camargo, Milena; Sánchez, Ricardo; Moreno Pérez, Darwin Andrés; Pérez - Prados, Antonio; Patarroyo, Manuel Elkin; Patarroyo, Manuel (2017)

Investigating whether high-risk human papillomavirus (HR-HPV) types tend to become grouped in a particular way and whether factors are associated with such grouping is important for measuring the real impact of vaccination. ...
The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents

Ríos Ospina, Luisa; Soto de León, Sara Cecilia; Camargo, Milena; Sánchez, Ricardo; Mancilla, Cindy Lizeth; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alonso (2016)

This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for ...

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Association of HIV status with infection by multiple HPV types
...
Camargo, Milena | 2018

Objectives: To identify the clinical and demographic characteristics of HIV-positive and HIV-negative women infected by multiple HPV types. Methods: 1399 women participated in the study (240 HIV-positive and 1159 HIV-negative women). Samples were provided for Pap tests and for HPV detection and typing by PCR. Data were collected on HPV infection, frequency of multiple infection, and HPV type distribution. Odds ratios were reported from logistic regression models. Results: Compared with HIV-negative women, HIV-positive women had higher frequencies of cervical abnormality (30% vs. 20.8%), higher HPV prevalence (68.3% vs. 51.3%) and were more commonly infected with multiple HPV types (78.7% vs. 44.3%). HPV-16 was the most common type detected in the study population, with other types showing variable associations with HIV status. Positive associations were observed between infection by multiple HPV types and HIV status, cervical abnormality and having had more than three pregnancies. The odds of multiple infection by HPV types were higher in HIV-positive women who used an intrauterine device, who had a history of abortions and who had HIV viral loads >100 000 copies/ml, whilst the odds were lower in women with >500 CD4 cells/mm 3 . Conclusions: HIV immunosuppression favours infection by multiple high-risk HPV types, mainly in women affected by low-grade squamous intraepithelial lesions. Antiretroviral therapy had no effect on infection by multiple HPV types. Risk factors related to progressive damage to the cervix were positively associated with infection by multiple HPV types in women living with HIV.

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Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors
...
Del Río-Ospina, Luisa | 2017

Investigating whether high-risk human papillomavirus (HR-HPV) types tend to become grouped in a particular way and whether factors are associated with such grouping is important for measuring the real impact of vaccination. In total, 219 women proving positive for HPV as detected by real-time PCR were included in the study. Each sample was analysed for detecting and quantifying six viral types and the hydroxymethylbilane synthase gene. Multiple correspondence analysis led to determining grouping patterns for six HR-HPV types and simultaneous association with multiple variables and whether viral load was related to the coexistence of other viral types. Two grouping profiles were identified: the first included HPV-16 and HPV-45 and the second profile was represented by HPV-31, HPV-33 and HPV-58. Variables such as origin, contraceptive method, births and pregnancies, educational level, healthcare affiliation regime, atypical squamous cells of undetermined significance and viral load were associated with these grouping profiles. Different socio-demographic characteristics were found when coinfection occurred by phylogenetically related HPV types and when coinfection was due to non-related types. Biological characteristics, the number of viral copies, temporality regarding acquiring infection and competition between viral types could influence the configuration of grouping patterns. Characteristics related to women and HPV, influence such interactions between coexisting HPV types reflecting the importance of their evaluation

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The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
...
Ríos Ospina, Luisa | 2016

This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.

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Browsing by Subject "Infecciones por Papillomavirus"

Association of HIV status with infection by multiple HPV types ﻿

Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors ﻿

The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents ﻿

Envíos recientes

Association of HIV status with infection by multiple HPV types

Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors

The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents

Association of HIV status with infection by multiple HPV types

Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors

The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents