Browsing by Subject "Immune response"

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Plasmodium falciparum pre-erythrocytic stage vaccine development

Molina Franky, Jessica; Cuy Chaparro, Laura; Camargo, Anny; Reyes, César; Gómez, Marcela; Salamanca, David Ricardo; Patarroyo, Manuel Alfonso; Patarroyo, Manuel Elkin (2020)

Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites (mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence rates. Many biologically-derived anti-malarial ...
What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?

López, Carolina; Yepes Pérez, Yoelis; Hincapie Escobar, Natalia; Díaz-Arévalo, Diana; Patarroyo, Manuel A. (2017)

Malaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an ...

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Plasmodium falciparum pre-erythrocytic stage vaccine development
...
Molina Franky, Jessica | 2020

Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites (mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence rates. Many biologically-derived anti-malarial vaccine candidates have been developed to date; this has involved using many experimental animals, an immense amount of work and the investment of millions of dollars. This review provides an overview of the current state and the main results of clinical trials for sporozoite-targeting vaccines (i.e. the parasite stage infecting the liver) carried out by research groups in areas having variable malaria transmission rates. However, none has led to promising results regarding the effective control of the disease, thereby making it necessary to complement such efforts at finding/introducing new vaccine candidates by adopting a multi-epitope, multi-stage approach, based on minimal subunits of the main sporozoite proteins involved in the invasion of the liver.

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What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?
...
López, Carolina | 2017

Malaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced by P. vivax.

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Browsing by Subject "Immune response"

Plasmodium falciparum pre-erythrocytic stage vaccine development ﻿

What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates? ﻿

Envíos recientes

Plasmodium falciparum pre-erythrocytic stage vaccine development

What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?

Plasmodium falciparum pre-erythrocytic stage vaccine development

What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?