Determinación de interleuquina seis (il-6) y proteína c reactiva (pcr) en pacientes con Inflamación renal
Meza Barreto, Giovanna | 1999-07
Inflammation is the first defense mechanism mastered by live tissues tacing a physical,Chemical or biological aggression. Within these the inmunocomplexes are found, which in a given moment can be the direct responsibles of the infiammatory response activation at renal level, mainly glomerular, with commitment of the cellular and humoral immunity. This process is mediated by proinflammatory cytokines as interlenkin - 6 IL - 8, IL - 1, factor of necrosis tumoral alpha (TNF alpha) and acute phase proteins like C-reactive protein (PCR), a-seric Amiloide and fibrinogen. In order to know the role of the two proteins in the mentioned pathology, the levels of IL-6 and PCR in serum and uriñe samples of patients with inflammation renal were determined. Furthermore their relationship was studied, since IL-6 acts on the hepatocyte inducing the production of acute phase proteins. The results showed a no significant difference between the IL-6 urinary valúes of the study and the control group. In 55% of the patients the serum PCR valúes were higher than 6 mg/l while in the rest, it was lower. The uriñe sample of one patient presented a significant concentration of this protein, important finding since PCR han not been determined in uriñe before. No direct realtionship between the IL-6 and PCR leves was detected in the analyzed samples.