Sarcoma histiocitico mediastinico en un perro Bernés de la Montaña
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Herrera Alfonso, Brayan David | 2018
Histiocytes are a subclassification of leukocytes, whose main function is essentially directed to the immune system, these cells are derived from the bone marrow from CD34 + precursor cells that form two types of cell lines monocytes / macrophages and dendritic cells (Rivers 2009). Histiocytic sarcoma can present in diverse localized, disseminated forms, it can occur in skin, bones, joints and lungs (Alvares 2013). Disseminated histiocytic sarcoma affects multiple systems & organs at the same time (Pessati 2014). Clinical signs will vary according to their anatomical location, and will show non-specific signs such as lethargy, decreased appetite, weight loss especially in patients with internal or visceral lesions (Affolter and Moore, 2002). Although CNS involvement has been recognized in dogs with disseminated (secondary) histiocytic sarcoma, reports of primary histiocytic sarcoma confined to the CNS are uncommon and most describe unique cases and small numbers of dogs (Coomer, 2008). Histiocytic sarcomas have been reported in many breeds, mainly in mountain berries, retriever, rottweiler, bullmastiff from middle to older (Rios 2009). In the following article we will present a case of a canine bernese from the mountain 4 years old who was diagnosed with a mediastinal histiocytic sarcoma. The purpose of this report is to gather scientific information of clinical, diagnostic and pathological findings as well as treatments that are used in dogs diagnosed with histiocytic sarcoma.eywords: histiocytes, hemophagocytic, dendritic cells, sarcoma
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