Simulación de rutas de alteración de células de cuello uterino desde el estado normal hasta lesión intraepitelial de bajo grado
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Rodríguez, Javier | 2014-01
A mathematical diagnosis of cells from cervicovaginal
cytology was previously developed establishing objective
and reproducible characterizations for different stages of
cellular disturbance from normality to carcinoma. In this
paper we start from this methodology to establish possible
routes of preneoplastic alteration from normal to L-SIL.
Ten digital images of squamous cells of cervix uterine with
normal diagnosis were studied. The images were analyzed
through a software with which fractal dimension of defined
mathematical objects was calculated. Fractal variability and
Cellular Intrinsic Mathematical Harmony (IMH) values were
calculated for each sample. From these values, simulations
of disturbances paths of each normal cell towards to L-SIL
cell were realized, doing three possible variations of spaces
of cellular occupation in Box-counting space. A possible
disturbance path towards to L-SIL state for each normal
cell was established. Each path is defined by three variation
possibilities of spaces of occupation of defined objects.
Each possibility can exhibit mathematical characteristics of
intermediate states of disturbance. Fractal dimension values
of the three defined objects in normal cells: cytoplasm,
nucleus and totality were between 1.0512 y 1.9944. Variability
and IMH values were between 0 and 6. A fractal organization
of cervix cellular structure was evidenced allowing to establish
simulation of disturbance. This finding can represent a useful
tool in clinical practice.
LEER