Now showing items 1-10 of 10

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

Ojeda a, Diego A.; L. Niño, Carmen; López León, Sandra; Camargo, Andrés; Adan, Ana; Forero, Diego A. (2014-02)

Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of EDS in the general population ...
International optimism: Correlates and consequences of dispositional optimism across 61 countries

Baranski, Erica; Sweeny, Kate; Gardiner, Gwendolyn; Funder, David C; Camargo, Andrés (2020)

The current exploratory study sought to examine dispositional optimism, or the general expectation for positive outcomes, around the world. Method: Dispositional optimism and possible correlates were assessed across 61 ...
Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns

Pereira-Morales, Angela J.; Adan, Ana; Casiraghi, Leandro P.; Camargo, Andrés (London, New York : Springer Nature, 2019, 2019)

While social zeitgebers are known to shape diurnal preference, little research has been devoted to determining the contribution of the familiar group chronotype as social zeitgeber on individual circadian rhythms and ...
Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults

Pereira Morales, Angela J.; Casiraghi, Leandro P.; Adan, Ana; Camargo, Andrés (2019)

mong the factors that contribute to the onset and maintenance of depressive disorders, rhythmicity of symptoms and consumption of caffeine have recently gained attention. The current study aimed to examine the differential ...
No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

González Giraldo, Yeimy; Camargo, Andrés; López León, Sandra; Forero, Diego A. (2015)

Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related ...
No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

González Giraldo, Yeimy; Camargo, Andrés; López León, Sandra; A. Forero, Diego (2015)

Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related ...
A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales

Ojeda, Diego A.; S. Perea, Claudia; Nino, Carmen L.; M. Gutiérrez, Rafael; López León, Sandra; Arboleda, Humberto; Camargo, Andrés (2013-10)

The circadian system is responsible for the generation and maintenance of physiological and behavioral rhythms in mammals and allows synchronization with the environment. Different polymorphisms in clock genes have been ...
Papel de los profesionales de la salud en el diseño, obtención y entendimiento del consentimiento informado: Una revisión

Camargo, Andrés; Olmos, Jessica; Higuera Dagovett, Elkin; Vargas, Rafael; Barreto, Ruth (Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019, 2019-07)

El consentimiento informado es un proceso que tiene la intención de autorizar o llegar a un acuerdo con el profesional para la realización de un procedimiento en el área de la salud o en el campo de la investigación, que ...
Psychological distress among undergraduate medical students: the influence of excessive daytime sleepiness and family functioning

Pereira Morales, Angela J.; Camargo, Andrés (2019)

Mental health problems among undergraduate medical students is a well-known issue; however, their associated risk factors have been poorly studied. We aimed to assess the hypothesis that medical students have a higher ...
Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors

Pereira-Morales, Angela J.; Adan, Ana; Camargo, Andrés; Forero, Diego A. (2017)

Background and Objectives: Young adults might engage in many risk behaviors, including alcohol and drug use, which could lead to mental health problems, such as suicide. The aim of this study was to examine specific ...

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A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects
...
Ojeda a, Diego A. | 2014-02

Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of EDS in the general population around the world ranges from 6.2 to 32.4%, with a heritability of 38–40%. However, few studies have explored the role of candidate genes in EDS. Monoamine oxidase A (MAOA) gene has an important role in the regulation of neurotransmitter levels and a large number of human behaviors. We hypothesized that a functional VNTR in the promoter region of the MAOA gene might be associated with daytime sleepiness in healthy individuals. The Epworth sleepiness scale (ESS) was applied to 210 Colombian healthy subjects (university students), which were genotyped for MAOA-uVNTR. MAOA-uVNTR showed a significant association with ESS scores (p = 0.01): 3/3 genotype carriers had the lowest scores. These results were supported by differences in MAOA-uVNTR frequencies between diurnal somnolence categories (p = 0.03). Our finding provides evidence for the first time that MAOA-uVNTR has a significant association with EDS in healthy subjects. Finally, these data suggest that functional variations in MAOA gene could have a role in other phenotypes of neuropsychiatric relevance.

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International optimism: Correlates and consequences of dispositional optimism across 61 countries
...
Baranski, Erica | 2020

The current exploratory study sought to examine dispositional optimism, or the general expectation for positive outcomes, around the world. Method: Dispositional optimism and possible correlates were assessed across 61 countries (N = 15,185; mean age = 21.92; 77% female). Mean-level differences in optimism were computed along with their relationships with individual and country-level variables. Results: Worldwide, mean optimism levels were above the midpoint of the scale. Perhaps surprisingly, country-level optimism was negatively related to gross domestic product per capita, population density, and democratic norms and positively related to income inequality and perceived corruption. However, country-level optimism was positively related to projected economic improvement. Individual-level optimism was positively related to individual well-being within every country, although this relationship was less strong in countries with challenging economic and social circumstances. Conclusions: While individuals around the world are generally optimistic, societal characteristics appear to affect the degree to which their optimism is associated with psychological well-being, sometimes in seemingly anomalous ways. © 2020 Wiley Periodicals LLC.

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Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns
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Pereira-Morales, Angela J. | 2019

While social zeitgebers are known to shape diurnal preference, little research has been devoted to determining the contribution of the familiar group chronotype as social zeitgeber on individual circadian rhythms and sleep-wake patterns in adult subjects. The current study aimed to examine the matching between perceived family chronotype and individual chronotype and their relationship with sleep-wake patterns on weekdays and weekends, diurnal subjective somnolence, and substance consumption. Nine hundred and forty-two Colombian adults completed the Composite Scale of Morningness, the Epworth Sleepiness Scale, and responded to a questionnaire about circadian preferences of their family nucleus. We found evidence of a mismatch between perceived family and individual chronotype, mainly for morning-type individuals (Cohen’s Kappa = −0.231; p < 0.001). This mismatch was associated with diurnal subjective somnolence (β = 0.073; p < 0.001) and specific sleep-wake patterns (p < 0.01). In addition, subjects with evening-type families showed higher caffeine and alcohol consumption (p < 0.001). To our knowledge, this is the first study to assess and report the mismatching between perceived family and individual chronotypes, and it adds to the existing body of knowledge regarding the influence of social zeitgebers on circadian rhythms. This is particularly relevant since mismatching between circadian physiology and environmental cues have been shown to lead to diverse pathologies. © 2019, The Author(s).

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Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults
...
Pereira Morales, Angela J. | 2019

mong the factors that contribute to the onset and maintenance of depressive disorders, rhythmicity of symptoms and consumption of caffeine have recently gained attention. The current study aimed to examine the differential rhythmicity of relevant variables in a sample of young participants, considering the presence of depressive symptomatology and the frequency of caffeinated drinks consumption. A significant 24-hour differential rhythmicity of mood, cognitive and physiological variables was found indicating an evening peak pattern in the participants with depressive symptoms. Interestingly, caffeinated drinks consumption was differentially associated with self-perceived peaks, according to the presence of depressive symptomatology. Our findings are among the first reports about the potential association of the 24-hours rhythmicity of relevant mood-related variables, depressive symptoms, and caffeine intake. These results support the view that the identification of risk factors for depression, and the application of novel measurements and analysis methods in the development of new preventive strategies should be a public health priority.

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No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects
...
González Giraldo, Yeimy | 2015

Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results. The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects. Methods and Materials. The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects. Five functional polymorphisms were genotyped using PCR-based assays: BDNF-Val66Met (rs6265), COMT-Val158Met (rs4680), SLC6A4-HTTLPR (rs4795541), MAOA-uVNTR, and SLC6A3-VNTR (rs28363170). Result. We did not find significant associations with scores of depressive symptoms, derived from the HADS, for any of the five candidate genes (nominal values >0.05). In addition, we did not find evidence of significant gene-gene interactions. Conclusion. This work is one of the first studies of candidate genes for depressive symptoms in a Latin American sample. Study of additional genetic and epigenetic variants, taking into account other pathophysiological theories, will help to identify novel candidates for MDD in populations around the world.

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No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects
...
González Giraldo, Yeimy | 2015

Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results. The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects. Methods and Materials. The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects. Five functional polymorphisms were genotyped using PCR-based assays: BDNF-Val66Met (rs6265), COMT-Val158Met (rs4680), SLC6A4-HTTLPR (rs4795541), MAOA-uVNTR, and SLC6A3-VNTR (rs28363170). Result. We did not find significant associations with scores of depressive symptoms, derived from the HADS, for any of the five candidate genes (nominal values >0.05). In addition, we did not find evidence of significant gene-gene interactions. Conclusion. This work is one of the first studies of candidate genes for depressive symptoms in a Latin American sample. Study of additional genetic and epigenetic variants, taking into account other pathophysiological theories, will help to identify novel candidates for MDD in populations around the world.

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A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales
...
Ojeda, Diego A. | 2013-10

The circadian system is responsible for the generation and maintenance of physiological and behavioral rhythms in mammals and allows synchronization with the environment. Different polymorphisms in clock genes have been studied in healthy humans, providing inconsistent results in different populations. In this study, we evaluated the possibility that two non-synonymous polymorphisms in PER2 (p.Gly1244Glu, rs934945) and PER3 (p.Met1028Thr, rs2640909) genes might be associated with diurnal preference in healthy Colombian subjects. A total of 209 Colombian university students were genotyped for two functional polymorphisms in PER2 and PER3 genes (rs934945 and rs2640909). We applied the composite scale of morningness (CSM) to measure phenotypic patterns of human diurnal preference. Additionally, we extracted from the CSM three subscale scores (“morningness”, “activity planning” and “morning alertness”).We used a false discovery rate approach (q values)for correction of multiple testing. PER2 (rs934945) showed a significant association with two CSM subscale scores: “activity planning” and “morning alertness”. For PER3 (rs2640909), we observed an association with the “morningness” CSM subscale scores. We found a significant association between novel and functional polymorphisms in PER2 and PER3 genes with specific CSM subscales for diurnal preference. We showed for the first time the association of rs934945 with “morning alertness” and rs2640909 with “morningness”. We suggest that these results should be replicated in order to confirm the association in other populations. Finally, the study of additional novel functional polymorphisms in other clock genes could be of relevance for a deep understanding of circadian phenotypes and neuropsychiatric disorders

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Papel de los profesionales de la salud en el diseño, obtención y entendimiento del consentimiento informado: Una revisión
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Camargo, Andrés | 2019-07

El consentimiento informado es un proceso que tiene la intención de autorizar o llegar a un acuerdo con el profesional para la realización de un procedimiento en el área de la salud o en el campo de la investigación, que se formaliza con la firma de un documento. Este consentimiento refleja la voluntad y la autonomía de dicho individuo y su capacidad, una vez ilustrado en detalle sobre la intervención, para entender los resultados principales y los potenciales riesgos de dicha intervención y su voluntad de asumirlos, sin presión externa. Aunque esto parece trivial, la historia muestra que voluntad y autonomía no han sido valores tenidos en cuenta en el área de la salud y menos en el campo de la investigación, de manera intencional o por omisión. Para la presente revisión, se realizó una búsqueda bibliográfica en las bases de datos PubMed, Medline, Scielo y Google Académico. Se utilizaron los siguientes descriptores: historia de la investigación, ética, consentimiento informado, investigación, enfermería y comprensión, encontrando 2.800 artículos, en idiomas inglés, portugués y español, sin restricción de un límite de tiempo; luego, se efectuó la lectura del resumen de los artículos, seleccionando los 80 que más se acercaban al tema y se emplearon. Como resultado del análisis de la información, se generaron algunas pautas orientadas a mejorar el proceso de consentimiento informado, a través de técnicas que mejoren la explicación por parte del profesional de salud y la comprensión del participante o paciente.

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Psychological distress among undergraduate medical students: the influence of excessive daytime sleepiness and family functioning
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Pereira Morales, Angela J. | 2019

Mental health problems among undergraduate medical students is a well-known issue; however, their associated risk factors have been poorly studied. We aimed to assess the hypothesis that medical students have a higher prevalence of psychological distress and to explain this prevalence considering common risk factors for mental disorders. This was a cross-sectional, questionnaire-based descriptive study conducted with 467 Colombian undergraduate medical students from different years of training. Validated and widely used self-report questionnaires of psychological distress, daytime sleepiness, and family functioning were included. In addition, measurements of smoking, alcohol, and caffeine intake were used. We found a prevalence of psychological distress, depressive symptoms and anxiety symptomatology of 65.9%, 75.3%, and 50.5%, respectively. Furthermore, 20.6% showed both psychological distress and excessive daytime sleepiness. Adjusted risk ratio analysis showed that poor family functioning, the presence of excessive daytime sleepiness, and caffeine consumption were significant risk factors for high levels of psychological distress. Additionally, psychological distress and daytime sleepiness were related to the year of training. Our results replicate in part previous findings of poor mental health among undergraduate medical students compared with mental health in general population and provide novel findings that family functioning plays a significant role as an important explanatory factor. The current study has high relevance for future research and interventions focused on prevention of medical errors, conflicts in the physician–patient relationship and the personal safety of undergraduate medical students.

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Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors
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Pereira-Morales, Angela J. | 2017

Background and Objectives: Young adults might engage in many risk behaviors, including alcohol and drug use, which could lead to mental health problems, such as suicide. The aim of this study was to examine specific psychosocial and clinical factors that could influence the possible relationship between polysubstance use (PSU) and suicide risk in a sample of young Colombian participants. Methods: A sample of 274 young participants (mean age = 21.3 years) was evaluated with two substance use screening tests (ASSIST and AUDIT) and five scales for clinical and psychosocial factors and suicide risk: The Center for Epidemiologic Studies Depression scale, Zung Self-Rating Anxiety scale, Family APGAR, the Childhood Trauma Questionnaire, and the Plutchik Suicide Risk scale. Correlation and multiple regression analyses were conducted. Results: Use of cannabis and tobacco was significantly correlated with suicide risk in the total sample (p <.05). Depressive and anxiety symptoms, family functioning, and emotional abuse during childhood were significantly associated with suicide risk (p <.001), while alcohol use, anxiety symptoms, and family functioning were variables significantly related to PSU. Discussion and Conclusions: Our findings are consistent with previous evidence suggesting a relationship between substance use, several psychosocial factors, and suicide risk in young participants. Scientific Significance: Our study is one of the first reports the relationship between substance use and suicide risk in a Latin American population. (Am J Addict 2017;26:388–394). © 2017 American Academy of Addiction Psychiatry

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Browsing by Author "Camargo, Andrés"

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects ﻿

International optimism: Correlates and consequences of dispositional optimism across 61 countries ﻿

Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns ﻿

Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults ﻿

No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects ﻿

No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects ﻿

A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales ﻿

Papel de los profesionales de la salud en el diseño, obtención y entendimiento del consentimiento informado: Una revisión ﻿

Psychological distress among undergraduate medical students: the influence of excessive daytime sleepiness and family functioning ﻿

Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors ﻿

Envíos recientes

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

International optimism: Correlates and consequences of dispositional optimism across 61 countries

Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns

Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults

No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales

Papel de los profesionales de la salud en el diseño, obtención y entendimiento del consentimiento informado: Una revisión

Psychological distress among undergraduate medical students: the influence of excessive daytime sleepiness and family functioning

Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

International optimism: Correlates and consequences of dispositional optimism across 61 countries

Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns

Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults

No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects

A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales

Papel de los profesionales de la salud en el diseño, obtención y entendimiento del consentimiento informado: Una revisión

Psychological distress among undergraduate medical students: the influence of excessive daytime sleepiness and family functioning

Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors