Browsing by Author "Bermúdez, Adriana"

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Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective

Curtidor, Hernando; Reyes, César; Bermúdez, Adriana; Vanegas, Magnolia; Varela, Yahson; Patarrollo, Manuel Elkin (2017)

Abstract: Synthetic peptides have become invaluable biomedical research and medicinal chemistry tools for studying functional roles, i.e., binding or proteolytic activity, naturally-occurring regions’ immunogenicity in ...
Functionally relevant proteins in Plasmodium falciparum host cell invasion

Patarroyo, Manuel Elkin; Alba, Martha Patricia; Rojas Luna, Rocío; Bermúdez, Adriana; Aza-Conde, Jorge (Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2017, 2017)

A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins ...

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Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective
...
Curtidor, Hernando | 2017

Abstract: Synthetic peptides have become invaluable biomedical research and medicinal chemistry tools for studying functional roles, i.e., binding or proteolytic activity, naturally-occurring regions’ immunogenicity in proteins and developing therapeutic agents and vaccines. Synthetic peptides can mimic protein sites; their structure and function can be easily modulated by specific amino acid replacement. They have major advantages, i.e., they are cheap, easily-produced and chemically stable, lack infectious and secondary adverse reactions and can induce immune responses via T- and B-cell epitopes. Our group has previously shown that using synthetic peptides and adopting a functional approach has led to identifying Plasmodium falciparum conserved regions binding to host cells. Conserved high activity binding peptides’ (cHABPs) physicochemical, structural and immunological characteristics have been taken into account for properly modifying and converting them into highly immunogenic, protection-inducing peptides (mHABPs) in the experimental Aotus monkey model. This article describes stereo–electron and topochemical characteristics regarding major histocompatibility complex (MHC)-mHABP-T-cell receptor (TCR) complex formation. Some mHABPs in this complex inducing long-lasting, protective immunity have been named immune protection-inducing protein structures (IMPIPS), forming the subunit components in chemically synthesized vaccines. This manuscript summarizes this particular field and adds our recent findings concerning intramolecular interactions (H-bonds or π-interactions) enabling proper IMPIPS structure as well as the peripheral flanking residues (PFR) to stabilize the MHCII-IMPIPS-TCR interaction, aimed at inducing long-lasting, protective immunological memory

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Functionally relevant proteins in Plasmodium falciparum host cell invasion
...
Patarroyo, Manuel Elkin | 2017

A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function.

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Browsing by Author "Bermúdez, Adriana"

Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective ﻿

Functionally relevant proteins in Plasmodium falciparum host cell invasion ﻿

Envíos recientes

Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective

Functionally relevant proteins in Plasmodium falciparum host cell invasion

Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective

Functionally relevant proteins in Plasmodium falciparum host cell invasion