Estudio preliminar de la estabilidad de una emulsión cosmética tipo "base"
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Bermúdez Carreño, Paula Andrea | 2019
BACKGROUND
Cosmetic products are used to clean, perfume, modify and / or protect the human body, the vast majority, act on the skin. For this, there are different types of cosmetics, such as perfumes, lipsticks, deodorants and / or antiperspirants, cosmetic emulsions, among others.
For skin care, the most commonly used cosmetic products are cosmetic emulsions (creams and bases), since they meet the definition of a cosmetic by modifying and protecting the skin of people, in some cases, their protection is through of sunscreens.
To ensure that the benefits of a cosmetic emulsion, in this case a cosmetic base, which has the properties of caring, moisturizing and protecting the skin with sunscreens, do not change dramatically as time goes by, stability studies should be performed, to demonstrate through qualitative and quantitative data that the base meets its purpose.
The stability studies allow estimating an approximate useful life time through the possible reactions or interactions of the components through physical and / or chemical changes that the formulation may have through different stress factors such as heat, humidity, vibration, light, degradation of assets, among others. This work has as main objective to study the stability of a cosmetic emulsion type “BASE” through different organoleptic and physicochemical tests that indicate the different results with which the behavior of the product can be evidenced and evaluated and in conjunction with the GALENO® program , confirm the Lifetime.
METHODS
The stability of the cosmetic emulsion type “BASE” was studied in the compatibility and industrial pilot stages under the condition to be evaluated at 40 ° C. The following tests were performed: organoleptic (Appearance, color, odor), viscosity, and quantification of active under the analysis times of: Initial time, first month, second month, third month and sixth month. Using the Galeno® software, predict the shelf life of the product by quantifying the asset (Benzophenone 3)
RESULTS
According to the results obtained in each of the stability study stages, of the BASE type cosmetic emulsion, to obtain a possible prediction of the shelf life of said product, the following findings were obtained As for its organoleptic characteristics for the two stages of stability study, the base-type cosmetic emulsion remains within specification and does not vary over time.
The physicochemical characteristic of viscosity does not show significant changes during the study time evaluated in the two study stages. However, a trend of continuous increase in viscosity is observed from the first month until the end of the study, due to the exposure of the base at a temperature of 40 ° C ± 2 ° C, possibly influencing the aqueous phase of the emulsion, since at this temperature, this component can generate a small percentage of evaporation, in addition, it can influence that the emulsifying agents are not in an adequate proportion, since these must keep the viscosity of the emulsion constant.
In the regression graph thrown by the Galeno® software, it can be determined that the TVU of the base-type cosmetic emulsion will have a time greater than 6 months. The percentage of degradation thrown by the program for the two stages of the study was 3,712%, indicating as an estimated prediction of TVU of 48 months.
CONCLUSIONS
The base-type cosmetic emulsion subjected to an accelerated condition stability study (40 ° C ± 2 ° C HR 75% ± 2%) under the compatibility and industrial pilot stages, maintained its physicochemical properties over time, a significant increase was found In the viscosity parameter due to the dispersed (oily) phase, however, it complied with the established specification, therefore, the product is stable in the study stages.
Comparing the TVU estimated by the R&D area of the makeup laboratory (24 months), and the data obtained by the Galeno® Software, using the Arrhenius formula, the program predicts a 48-month TVU which indicates that, after The estimated time, the base-type cosmetic emulsion will remain stable under extreme conditions (40 ° C ± 2 ° C).
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