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A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

Ojeda a, Diego A.; L. Niño, Carmen; López León, Sandra; Camargo, Andrés; Adan, Ana; Forero, Diego A. (2014-02)

Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of EDS in the general population ...
Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample

A. Ojeda, Diego; S. Perea, Claudia; Suárez, Annjy; L. Niño, Carmen; M. Gutiérrez, Rafael; López León, Sandra; Adan, Ana (2014-01)

The molecular study of circadian rhythms in humans could be an excellent approach to understand the relation between genes and behavior. It is possible that variations in genes involved in neurotransmission and/or synaptic ...
Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns

Pereira-Morales, Angela J.; Adan, Ana; Casiraghi, Leandro P.; Camargo, Andrés (London, New York : Springer Nature, 2019, 2019)

While social zeitgebers are known to shape diurnal preference, little research has been devoted to determining the contribution of the familiar group chronotype as social zeitgeber on individual circadian rhythms and ...
Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults

Pereira Morales, Angela J.; Casiraghi, Leandro P.; Adan, Ana; Camargo, Andrés (2019)

mong the factors that contribute to the onset and maintenance of depressive disorders, rhythmicity of symptoms and consumption of caffeine have recently gained attention. The current study aimed to examine the differential ...
Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors

Pereira-Morales, Angela J.; Adan, Ana; Camargo, Andrés; Forero, Diego A. (2017)

Background and Objectives: Young adults might engage in many risk behaviors, including alcohol and drug use, which could lead to mental health problems, such as suicide. The aim of this study was to examine specific ...

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A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects
...
Ojeda a, Diego A. | 2014-02

Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of EDS in the general population around the world ranges from 6.2 to 32.4%, with a heritability of 38–40%. However, few studies have explored the role of candidate genes in EDS. Monoamine oxidase A (MAOA) gene has an important role in the regulation of neurotransmitter levels and a large number of human behaviors. We hypothesized that a functional VNTR in the promoter region of the MAOA gene might be associated with daytime sleepiness in healthy individuals. The Epworth sleepiness scale (ESS) was applied to 210 Colombian healthy subjects (university students), which were genotyped for MAOA-uVNTR. MAOA-uVNTR showed a significant association with ESS scores (p = 0.01): 3/3 genotype carriers had the lowest scores. These results were supported by differences in MAOA-uVNTR frequencies between diurnal somnolence categories (p = 0.03). Our finding provides evidence for the first time that MAOA-uVNTR has a significant association with EDS in healthy subjects. Finally, these data suggest that functional variations in MAOA gene could have a role in other phenotypes of neuropsychiatric relevance.

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Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample
...
A. Ojeda, Diego | 2014-01

The molecular study of circadian rhythms in humans could be an excellent approach to understand the relation between genes and behavior. It is possible that variations in genes involved in neurotransmission and/or synaptic plasticity, such as catechol-O-methyltransferase (COMT) and serotonin transporter (SLC6A4) could be of particular interest in understanding human circadian phenotypes. The aim of this study is to analyze the possible and novel associations of the functional polymorphisms in COMT and SLC6A4 genes (Val158Met and 5-HTTLPR) and circadian phenotypes in healthy Colombian subjects. 191 university students were genotyped for two functional polymorphisms in COMT and SLC6A4 genes (rs4680 and rs4795541). We applied two scales to measure phenotypic patterns of human circadian rhythms: Composite Scale of Morningness (CSM) and Epworth Sleepiness Scale (ESS). We found a significant association between 5-HTTLPR polymorphism and morning preference score (CSM) (p = 0.027) using an overdominant genotypic model and association of COMT Val158Met with daytime sleepiness (ESS scores) (p = 0.038) in a genotypic recessive model. These results were supported by differences in genotype frequencies between circadian typologies for SLC6A4 gene (p = 0.007) and categories of diurnal sleepiness for COMT gene (p = 0.032). Our results suggest, for the first time, a significant relationship between functional SLC6A4 and COMT polymorphisms with specific human circadian phenotypes: morning preference and diurnal sleepiness. These results need to be replicated in other populations. Further study of functional polymorphisms in other synaptic genes could be of relevance for the identification of novel candidate genes for circadian phenotypes, and related endophenotypes of neuropsychiatric importance, in healthy humans.

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Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns
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Pereira-Morales, Angela J. | 2019

While social zeitgebers are known to shape diurnal preference, little research has been devoted to determining the contribution of the familiar group chronotype as social zeitgeber on individual circadian rhythms and sleep-wake patterns in adult subjects. The current study aimed to examine the matching between perceived family chronotype and individual chronotype and their relationship with sleep-wake patterns on weekdays and weekends, diurnal subjective somnolence, and substance consumption. Nine hundred and forty-two Colombian adults completed the Composite Scale of Morningness, the Epworth Sleepiness Scale, and responded to a questionnaire about circadian preferences of their family nucleus. We found evidence of a mismatch between perceived family and individual chronotype, mainly for morning-type individuals (Cohen’s Kappa = −0.231; p < 0.001). This mismatch was associated with diurnal subjective somnolence (β = 0.073; p < 0.001) and specific sleep-wake patterns (p < 0.01). In addition, subjects with evening-type families showed higher caffeine and alcohol consumption (p < 0.001). To our knowledge, this is the first study to assess and report the mismatching between perceived family and individual chronotypes, and it adds to the existing body of knowledge regarding the influence of social zeitgebers on circadian rhythms. This is particularly relevant since mismatching between circadian physiology and environmental cues have been shown to lead to diverse pathologies. © 2019, The Author(s).

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Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults
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Pereira Morales, Angela J. | 2019

mong the factors that contribute to the onset and maintenance of depressive disorders, rhythmicity of symptoms and consumption of caffeine have recently gained attention. The current study aimed to examine the differential rhythmicity of relevant variables in a sample of young participants, considering the presence of depressive symptomatology and the frequency of caffeinated drinks consumption. A significant 24-hour differential rhythmicity of mood, cognitive and physiological variables was found indicating an evening peak pattern in the participants with depressive symptoms. Interestingly, caffeinated drinks consumption was differentially associated with self-perceived peaks, according to the presence of depressive symptomatology. Our findings are among the first reports about the potential association of the 24-hours rhythmicity of relevant mood-related variables, depressive symptoms, and caffeine intake. These results support the view that the identification of risk factors for depression, and the application of novel measurements and analysis methods in the development of new preventive strategies should be a public health priority.

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Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors
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Pereira-Morales, Angela J. | 2017

Background and Objectives: Young adults might engage in many risk behaviors, including alcohol and drug use, which could lead to mental health problems, such as suicide. The aim of this study was to examine specific psychosocial and clinical factors that could influence the possible relationship between polysubstance use (PSU) and suicide risk in a sample of young Colombian participants. Methods: A sample of 274 young participants (mean age = 21.3 years) was evaluated with two substance use screening tests (ASSIST and AUDIT) and five scales for clinical and psychosocial factors and suicide risk: The Center for Epidemiologic Studies Depression scale, Zung Self-Rating Anxiety scale, Family APGAR, the Childhood Trauma Questionnaire, and the Plutchik Suicide Risk scale. Correlation and multiple regression analyses were conducted. Results: Use of cannabis and tobacco was significantly correlated with suicide risk in the total sample (p <.05). Depressive and anxiety symptoms, family functioning, and emotional abuse during childhood were significantly associated with suicide risk (p <.001), while alcohol use, anxiety symptoms, and family functioning were variables significantly related to PSU. Discussion and Conclusions: Our findings are consistent with previous evidence suggesting a relationship between substance use, several psychosocial factors, and suicide risk in young participants. Scientific Significance: Our study is one of the first reports the relationship between substance use and suicide risk in a Latin American population. (Am J Addict 2017;26:388–394). © 2017 American Academy of Addiction Psychiatry

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Browsing by Author "Adan, Ana"

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects ﻿

Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample ﻿

Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns ﻿

Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults ﻿

Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors ﻿

Envíos recientes

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample

Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns

Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults

Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample

Mismatch between perceived family and individual chronotype and their association with sleep-wake patterns

Mood rhythmicity is associated with depressive symptoms and caffeinated drinks consumption in South American young adults

Substance use and suicide risk in a sample of young Colombian adults: An exploration of psychosocial factors