• Invasion-inhibitory peptides chosen by natural selection analysis as an antimalarial strategy 

      Rodriguez-Obediente, Kewin ; Yepes-Pérez, Yoelis; Benavides-Ortiz, Daniel; Diaz-Arevalo, Diana; Reyes, César; Arevalo-Pinzon, Gabriela; Patarroyo, Manuel-Alfonso (2023)
      Plasmodium vivax's biological complexity has restricted in vitro culture development for characterising antigens involved in erythrocyte invasion and their immunological relevance. The murine model is proposed as a suitable ...
    • Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases 

      Reyes, César; Molina Franky, Jessica S.; Aza Conde, Jorge; Suárez, Carlos F.; Pabón, Laura; Moreno Vranich, Armando; Patarroyo, Manuel A.; Patarroyo, Manuel Elkin (2020)
      Malaria remains a large-scale public health problem, killing more than 400,000 people and infecting up to 230 million worldwide, every year. Unfortunately, despite numerous efforts and research concerning vaccine development, ...
    • Plasmodium falciparum pre-erythrocytic stage vaccine development 

      Molina Franky, Jessica; Cuy Chaparro, Laura; Camargo, Anny; Reyes, César; Gómez, Marcela; Salamanca, David Ricardo; Patarroyo, Manuel Alfonso; Patarroyo, Manuel Elkin (2020)
      Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites (mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence rates. Many biologically-derived anti-malarial ...
    • Self-assembling peptides: Perspectives regarding biotechnological applications and vaccine development 

      Reyes, César; Patarroyo, Manuel-Alfonso (2024)
      Self-assembly involves a set of molecules spontaneously interacting in a highly coordinated and dynamic manner to form a specific supramolecular structure having new and clearly defined properties. Many examples of this ...
    • SM-COLSARSPROT: Highly Immunogenic Supramutational Synthetic Peptides Covering the World’s Population 

      Patarroyo, Manuel-Alfonso; Patarroyo, Manuel-Elkin; Pabón, Laura; Alba, Martha patricia; Bermúdez, Adriana; Rugeles, María Teresa; Díaz-Arevalo, Diana; Zapata, María Isabel; Reyes, César; Suárez, Carlos F.; Agudelo, William; Zapata, Wildeman (2022)
      Fifty ~20–amino acid (aa)–long peptides were selected from functionally relevant SARS-CoV-2 S, M, and E proteins for trial B-21 and another 53 common ones, plus some new ones derived from the virus’ main genetic variants ...
    • The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development 

      Reyes, César; Moreno-Vranich, Armando; Patarroyo, Manuel Elkin (2017)
      Analysis of ourPlasmodium falciparummalaria parasite peptides'1H-NMR database in the search for H-bonds andp-interactions led us to correlate their presence or absence with a peptide's particularimmunological behavior. It ...