Listar por autor "Reyes, César"
Mostrando ítems 2-9 de 9
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Conserved binding regions provide the clue for peptide-based vaccine development: A chemical perspective
Curtidor, Hernando; Reyes, César; Bermúdez, Adriana; Vanegas, Magnolia; Varela, Yahson; Patarrollo, Manuel Elkin (2017)Abstract: Synthetic peptides have become invaluable biomedical research and medicinal chemistry tools for studying functional roles, i.e., binding or proteolytic activity, naturally-occurring regions’ immunogenicity in ... -
Critical role of HLA-DRb* binding peptides' peripheralflankingresidues in fully-protective malaria vaccine development
Reyes, César; Rojas-Luna, Rocío; Aza-Conde, Jorge; Tabares, Luisa; Patarroyo, Manuel-Alfonso; Patarroyo, Manuel-Elkin (2017)A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), ... -
Invasion-inhibitory peptides chosen by natural selection analysis as an antimalarial strategy
Rodriguez-Obediente, Kewin ; Yepes-Pérez, Yoelis; Benavides-Ortiz, Daniel; Diaz-Arevalo, Diana; Reyes, César; Arevalo-Pinzon, Gabriela; Patarroyo, Manuel-Alfonso (2023)Plasmodium vivax's biological complexity has restricted in vitro culture development for characterising antigens involved in erythrocyte invasion and their immunological relevance. The murine model is proposed as a suitable ... -
Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases
Reyes, César; Molina Franky, Jessica S.; Aza Conde, Jorge; Suárez, Carlos F.; Pabón, Laura; Moreno Vranich, Armando; Patarroyo, Manuel A.; Patarroyo, Manuel Elkin (2020)Malaria remains a large-scale public health problem, killing more than 400,000 people and infecting up to 230 million worldwide, every year. Unfortunately, despite numerous efforts and research concerning vaccine development, ... -
Plasmodium falciparum pre-erythrocytic stage vaccine development
Molina Franky, Jessica; Cuy Chaparro, Laura; Camargo, Anny; Reyes, César; Gómez, Marcela; Salamanca, David Ricardo; Patarroyo, Manuel Alfonso; Patarroyo, Manuel Elkin (2020)Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites (mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence rates. Many biologically-derived anti-malarial ... -
Self-assembling peptides: Perspectives regarding biotechnological applications and vaccine development
Reyes, César; Patarroyo, Manuel-Alfonso (2024)Self-assembly involves a set of molecules spontaneously interacting in a highly coordinated and dynamic manner to form a specific supramolecular structure having new and clearly defined properties. Many examples of this ... -
SM-COLSARSPROT: Highly Immunogenic Supramutational Synthetic Peptides Covering the World’s Population
Patarroyo, Manuel-Alfonso; Patarroyo, Manuel-Elkin; Pabón, Laura; Alba, Martha patricia; Bermúdez, Adriana; Rugeles, María Teresa; Díaz-Arevalo, Diana; Zapata, María Isabel; Reyes, César; Suárez, Carlos F.; Agudelo, William; Zapata, Wildeman (2022)Fifty ~20–amino acid (aa)–long peptides were selected from functionally relevant SARS-CoV-2 S, M, and E proteins for trial B-21 and another 53 common ones, plus some new ones derived from the virus’ main genetic variants ... -
The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development
Reyes, César; Moreno-Vranich, Armando; Patarroyo, Manuel Elkin (2017)Analysis of ourPlasmodium falciparummalaria parasite peptides'1H-NMR database in the search for H-bonds andp-interactions led us to correlate their presence or absence with a peptide's particularimmunological behavior. It ...