Envíos recientes

XIAP as a Target of New Small Organic Natural Molecules Inducing Human Cancer Cell Death

Muñoz, Diego | 2019

X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in cancer. We report on the discovery and characterisation of small organic molecules from Piper genus plants exhibiting XIAP antagonism, namely erioquinol, a quinol substituted in the 4-position with an alkenyl group and the alkenylphenols eriopodols A–C. Another isolated compound was originally identified as gibbilimbol B. Erioquinol was the most potent inhibitor of human cancer cell viability when compared with gibbilimbol B and eriopodol A was listed as intermediate. Gibbilimbol B and eriopodol A induced apoptosis through mitochondrial permeabilisation and caspase activation while erioquinol acted on cell fate via caspase-independent/non-apoptotic mechanisms, likely involving mitochondrial dysfunctions and aberrant generation of reactive oxygen species. In silico modelling and molecular approaches suggested that all molecules inhibit XIAP by binding to XIAP-baculoviral IAP repeat domain. This demonstrates a novel aspect of XIAP as a key determinant of tumour control, at the molecular crossroad of caspasedependent/ independent cell.

Zonas económicas homogéneas de la Sabana de Bogotá

Fonseca González, Valentina | 2017

El catastro es visto como herramienta principal para el cobro de impuestos y el ordenamiento territorial En la actualidad se vive en un mundo globalizado en donde la dinámica económica, política y social, conlleva a cambios que se manifiestan en el territorio en ese contexto, el catastro es una herramienta que tiene como objetivo documentar, mantener y actualizar la ordenación del espacio geográfico con tendencia al desarrollo inmobiliario, apoyado en tres pilares fundamentales de la propiedad inmobiliaria descripción física, situación jurídica y valor económico. A continuación se presentará la información más relevante obtenida en campo en el transcurso y desarrollo de las actividades propuestas para la salida de la asignatura de Catastro en el primer semestre del año 2017 así como estadísticas obtenidas de fuentes pertinentes y cercanas al catastro colombiano, permitiendo así realizar un análisis comparativo de las diferentes dinámicas que se presentan en cada uno de los municipios visitados ( Facatativá, El Rosal, Madrid, Mosquera, Tenjo)

Zonas homogéneas para manejo específico por sitio en maíz usando un sensor de inducción electromagnética en la sabana de Bogotá

Alfaro Rodríguez, Ricardo | 2015-07

Precision farming aims to improve production taking into account variability of the agricultural system. To do this, homogeneous management zones (HZ) are delimited within the crop field. The use of electromagnetic induction (EMI) sensors that record apparent electrical conductivity (ECa) allows to identify variations in soil properties and in turn to define quickly and reliably zones with similar characteristics. The research had as objective ZM delimitation for site-specific management (SSM) using an EMI sensor in soils under maize crops (Zea mays L.) at the Sabana de Bogotá. For this, two agricultural fields were chosen in Facatativá and Bojacá, and in them it was measured ECa and soil water content (Wsc). Maps of ECa and Wsc were drawn and three ZM were defined within each field. In these ZM, soil samples were taken for physicochemical laboratory analysis and it was determined plant height, SPAD index at 60 and 120 DDG and crop yield. Statistical analysis was performed with SPSS V22 and SAS V 2.5. The results showed correlations between ECa and content of silt in Bojacá and clay content in Facatativá, and statistically significant differences in maize yields between the ZM. This research highlights the utility of the IM sensor to define ZM for SSM.

Zonas prioritarias para la conservación de ecosistemas afectados por procesos de desertificación en la cuenca media del Río Chicamocha - Colombia

Ramírez Ramírez, Dayanna Lizeth | 2019

Desertification is understood as the degradation of land and is in a chemical or physical way. Is a problem that results in the loss of natural cycles, which entails the weakening of economic production and with it, the imbalance of the social structure that has been formed from the use of land. The objective of this work is to prioritize the zones for the conservation of the ecosystems, to demonstrate the ecosystem services of the support and the processes of desertification. The methodology has been done through three phases: the first was a description of the systems of the study area and the services of the media that are in. The second phase, through a multicriteria system was to determined the ecosystems in the basin that should be prioritized, and in the third phase, a proposal was made of the areas that should be prioritized by criteria proposed by the authors. As a general result we have a description of the WCR ecosystems, and the ecosystem services offered by them, besides the especialization of some support ecosystems they provide. Through the second phase, a map of the zones that should be protected was obtained, and on the third phase, three conservations zones were obtain, those zones can be implemented to mitigate the progressive progress of the phenomenon of desertification. It is concluded that the technical services have been corrected, the work in the field has confirmed the information in the cartography. Problematic activities such as desertification, in addition to what is stated in the municipalities of CMR, are implemented in the conservation of areas different from those defined by Corpoboyacá, to ensure its economic balance in the future.

Zonificación de áreas de amortiguamiento en la Cuenca del Lago de Tota (Análisis multivariable)

Lesmes Parra, María Camila | 2017

La cuenca del lago de Tota está ubicada en el departamento de Boyacá, entre los municipios de Aquitania, Tota y Cuítiva es considerada como una de la principal reserva de agua del país, su principal cuerpo de agua tiene una extensión de 85 km 2 aproximadamente, esta cuenca cuenta con ecosistemas de bosque alto andino y paramo, por lo que su riqueza de diversidad es gigante A pesar de esto, varios informes técnicos dan cuenta de la degradación de la cuenca en general, y la consecuente alteración ecológica, provocada por presiones antrópicas como la ampliación de la frontera agrícola, especialmente para cultivos de cebolla, que requieren de fertilizantes de gran impacto (algunos llegan hasta la laguna, por escorrentía) la ganadería, la piscicultura no sostenible, la ocupación de la ronda hídrica, y la demanda exagerada de agua en sus tres categorías ( agrícola e industrial) Por lo tanto la siguiente investigación está orientado al análisis de criterios y variables tales como la cobertura de la tierra, degradación del suelo y presión de contaminantes que afectan y alterar la cuenca del Lago de tota y de esta manera determinar su impacto para desarrollar una zonificación de amortiguación mediante la utilización de cartografía temática generada por la interrelación de variable

Zonificación de susceptibilidad a movimientos en masa en el área urbana del sector este de la UPZ Verbenal, Bogotá D.C

Caviedes Hernández, Liseth Yurany | 2021

Zum Status von Baumstachler und Baumratte in Kolumbien - Ein Aktiviätsbericht

Osbahr, Karin | 2013

The Fauna Research Group of the Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A.) in Bogotá, Colombia, as part of its research on hystricomorph rodents, has initiated an assessment of the status of four porcupine species: Echinoprocta rufescens, Sphiggurus vestitus, Coendou sanctamartae (family Erethizontidae) and the spiny rat Santamartamys rufodorsalis (family Echimyidae), which are rare and only found in mountainous ecosystems of Colombia. According to surveys, porcupines are frequently observed in the area of San Juan de Rioseco. Locals recognized several species in the field guide: Coendou prehensilis, C. bicolor and C. quichua. Two locals also identified S. vestitus. Near Santa Cruz Zoo, in the region San Antonio del Tequendama, specimens of C. prehensilis, C. bicolor, C. melanurus, C. quichua und E. rufescens were confirmed.